Poe Orb of Annulment is a currency item obtained by combining a full stack of Annulment Shards(which are dropped by harbingers inside the harbinger league). It could be utilized to remove a random modifier from magic or unique Poe item.
This orb is extra RNG pointlessness. You are going to find yourself bricking a minimum of dozens from the items merely to eliminate a single stat, to ensure that you'll be able to what, do a further amount of RNG to add stat?
Crafting in PoE is just highly-priced gambling. So here's the ridiculous RNG path you might take...
high-quality currency -> trans -> 100s of alts -> aug -> rinse & repeat -> regal -> rinse & repeat -> annul -> rinse & repeat -> exalt -> rinse & repeat -> finally a good item after wasting how much Poe currency?
It *can* take away the single lousy suffix and securely keep all prefixes (or vice versa with proper suffixes and wrong prefixes). With the master mods, but it *could* also take away the 'prefixes can't be changed' instead, forcing you to burn an additional Poe Exalted orb on it.

I mean, you'd be better off just using a scouring to wipe all suffixes to get rid of it for sure in one particular go (along with the 'prefixes can't be changed'). Unless you've got something like good prefixes and one particularly good suffix and one bad suffix, and you wanted to hedge your bets on getting the one particular bad suffix out.

In that case, you could master mod to keep the prefixes safe and have a 50/50 shot at getting rid in the lousy suffix without harming the right one particular.(well, 33/33/33 of getting the lousy suffix.

but if you hit the prefixes can't be changed you'd presumably replace it and try again, so long run it's 50/50 to get the lousy suffix before you hit the proper 1)
Besides, that inside the first ten days on the league people didn't take annulment orbs into account when pricing items. I could buy a lot of Items that were okay'ish but potentially significant. For instance gloves with high life and two proper suffixes but no room for attack speed enchant. Crafted a lot of those. Sold most and made a good profit (kept the ones I linked above and slammed the flat Phys).
Also had some terrible results where I destroyed weapons with the merciless roll.
All in all, it was the best thing from the entire league :D

Typically, they're not worth the problems for motives which might be adequate within the extended run. While they may be valuable for players, who could know nothing about the game. For one of the most aspect, they're learning tools for novices to ease them into the game. For a lot more Poe Guides, it is possible to take a look at Poecurrencybuy.com. Just a reminder: you can get 5% coupon code at no cost from the reps when you Invest in Poe Currency from this short article.